Dr. Sawyer: There is some evidence that various drugs/medications might reduce the effectiveness of the pill. Some antibiotics like tetracycline; anti-depressants, anti-fungal, and anti-anxiety medications might be a problem, and even herbal supplements like St. John’s Wort have been linked with this problem. The research evidence on this issue isn’t very definitive, hence a lot of “might’s” and “coulds” so this becomes pretty confusing. If a woman has any doubts about combining the pill with medication, she should absolutely consult her practitioner.